Chemically modified tetracyclines pdf
نویسنده
چکیده
Sepsis was induced by cecal ligation.Chemically modified tetracyclines CMTs are derivatives of tetracycline group of drugs which lack antimicrobial action but have potent host modulating affects.Chemically Modified Tetracyclines: An Emerging Host Modulatory Therapy. 1Sonakshi Gupta and 2 Vidya Dodwad. 1Postgraduate student III Yr, Department.of chemically modified tetracyclines CMTs on the production of gelatinases. Matrix metalloproteinase MMP-2 and -9 by human periodontal ligament PDL.ABSTRACT. Several chemically modified tetracycline analogs CMTs, which were chemically modified to eliminate their antibacterial efficacy, were.Periodontal disease, matrix metalloproteinases and chemically modified tetracyclines. 1, Pages 1-7 doi: 10.
منابع مشابه
A novel mechanism of action of chemically modified tetracyclines: inhibition of COX-2-mediated prostaglandin E2 production.
Tetracyclines (doxycycline and minocycline) inhibit inducible NO synthase expression and augment cyclooxygenase (COX)-2 expression and PGE2 production. In contrast, chemically modified tetracyclines (CMTs), such as CMT-3 and -8 (but not CMT-1, -2, and -5), that lack antimicrobial activity, inhibit both NO and PGE2 production in LPS-stimulated murine macrophages, bovine chondrocytes, and human o...
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